Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
adrb1_human 167 34.54x54 ICL2 Q => Ter stop gained 8.325e-06 1 120114 0 None None GP (contact)
adrb1_human 199 ECL2 W => Ter stop gained 8.763e-06 1 114110 0 None None LB (polar (hydrogen bond with backbone), Van der Waals)
adrb1_human 274 ICL3 S => Ter stop gained 8.56e-05 1 11682 0 None None PTM (Phosphorylation)
adrb1_human 370 7.46x46 TM7 S => Ter stop gained 8.977e-06 1 111396 0 None None
adrb1_human 378 7.54x54 TM7 C => SerfsTer213 frameshift 8.961e-06 1 111592 0 None None
adrb1_human 15 N-term N => S missense 0.02239 3 134 0 0.34 0.953
adrb1_human 29 N-term A => E missense 0.0009881 1 1012 0 0.04 0.992
adrb1_human 40 N-term A => D missense 0.0001774 1 5636 0 0.22 0.158
adrb1_human 41 N-term S => W missense 0.0001577 1 6342 0 0.0 0.769
adrb1_human 49 N-term S => G missense 0.304 13194 43402 1075 0.79 0.0
adrb1_human 52 1.26x26 TM1 P => R missense 3.181e-05 2 62874 0 0.35 0.03
adrb1_human 52 1.26x26 TM1 P => L missense 1.59e-05 1 62874 0 0.32 0.0
adrb1_human 58 1.32x32 TM1 T => I missense 1.083e-05 1 92310 0 0.15 0.194
adrb1_human 66 1.40x40 TM1 A => G missense 9.114e-06 1 109720 0 0.16 0.019
adrb1_human 81 1.55x55 TM1 V => L missense 1.711e-05 2 116892 0 0.23 0.026
adrb1_human 83 1.57x57 TM1 I => N missense 8.498e-06 1 117674 0 0.0 1.0
adrb1_human 87 12.48x48 ICL1 P => L missense 8.431e-06 1 118606 0 0.02 0.412
adrb1_human 92 2.38x38 TM2 L => F missense 8.361e-06 1 119610 0 0.02 0.999
adrb1_human 93 2.39x39 TM2 T => A missense 8.355e-06 1 119692 0 0.0 0.996
adrb1_human 106 2.52x52 TM2 V => L missense 8.299e-06 1 120496 0 0.09 0.294
adrb1_human 113 2.59x58 TM2 P => S missense 8.292e-06 1 120600 0 0.02 0.999
adrb1_human 117 2.63x62 TM2 T => S missense 8.29e-06 1 120628 0 0.34 0.462 LB (hydrophobic, aromatic (edge-to-face), Van der Waals)
adrb1_human 117 2.63x62 TM2 T => S missense 8.289e-06 1 120640 0 0.34 0.462 LB (hydrophobic, aromatic (edge-to-face), Van der Waals)
adrb1_human 118 2.64x63 TM2 I => V missense 8.288e-06 1 120658 0 0.48 0.175 LB (Van der Waals)
adrb1_human 127 3.21x21 TM3 G => S missense 8.286e-06 1 120680 0 0.01 1.0
adrb1_human 127 3.21x21 TM3 G => D missense 8.287e-06 1 120674 0 0.0 1.0
adrb1_human 129 3.23x23 TM3 F => L missense 8.286e-06 1 120686 0 0.03 0.517
adrb1_human 132 3.26x26 TM3 E => D missense 8.287e-06 1 120664 0 0.12 0.978
adrb1_human 134 3.28x28 TM3 W => R missense 8.289e-06 1 120638 0 0.0 1.0
adrb1_human 135 3.29x29 TM3 T => S missense 8.289e-06 1 120638 0 0.01 0.945
adrb1_human 143 3.37x37 TM3 T => P missense 1.658e-05 2 120614 0 0.0 0.999
adrb1_human 145 3.39x39 TM3 S => I missense 3.317e-05 4 120608 0 0.0 1.0
adrb1_human 151 3.45x45 TM3 V => A missense 8.294e-06 1 120574 0 0.17 0.998
adrb1_human 155 3.49x49 TM3 D => G missense 1.66e-05 2 120502 0 0.0 1.0 SodiumPocket MicroSwitch
adrb1_human 160 3.54x54 TM3 I => N missense 8.308e-06 1 120370 0 0.0 0.99 GP (contact)
adrb1_human 165 34.52x52 ICL2 R => G missense 1.663e-05 2 120232 0 0.0 0.997 GP (contact)
adrb1_human 172 4.39x39 TM4 R => P missense 8.379e-06 1 119344 0 0.0 0.921
adrb1_human 175 4.42x42 TM4 A => G missense 8.391e-06 1 119174 0 0.0 0.998
adrb1_human 176 4.43x43 TM4 R => Q missense 8.385e-06 1 119266 0 0.02 0.713
adrb1_human 181 4.48x48 TM4 T => A missense 8.383e-06 1 119284 0 0.22 0.025
adrb1_human 181 4.48x48 TM4 T => I missense 1.677e-05 2 119282 0 0.61 0.199
adrb1_human 187 4.54x54 TM4 A => V missense 3.356e-05 4 119194 0 0.06 0.874
adrb1_human 197 4.64x64 TM4 H => R missense 1.687e-05 2 118580 0 0.06 0.321
adrb1_human 197 4.64x64 TM4 H => L missense 8.433e-06 1 118580 0 0.0 0.321
adrb1_human 200 ECL2 R => L missense 8.689e-06 1 115090 0 0.04 0.629 LB (Van der Waals, polar (charge-assisted hydrogen bond))
adrb1_human 201 ECL2 A => G missense 8.892e-06 1 112460 0 0.17 0.005 LB (hydrophobic, Van der Waals, aromatic (edge-to-face), aromatic (face-to-edge), polar (hydrogen bond))
adrb1_human 205 ECL2 E => K missense 8.655e-06 1 115534 0 0.08 0.006
adrb1_human 208 ECL2 R => C missense 8.568e-06 1 116720 0 0.09 0.646 LB (Van der Waals, hydrophobic, polar (hydrogen bond))
adrb1_human 208 ECL2 R => P missense 8.562e-06 1 116794 0 0.12 0.29 LB (Van der Waals, hydrophobic, polar (hydrogen bond))
adrb1_human 212 ECL2 D => N missense 8.458e-06 1 118236 0 0.24 0.075 LB (Van der Waals)
adrb1_human 215 ECL2 C => Y missense 8.415e-06 1 118840 0 0.0 0.999 LB (Van der Waals, polar (hydrogen bond))
adrb1_human 219 ECL2 V => I missense 8.382e-06 1 119302 0 0.24 0.007
adrb1_human 222 5.36x37 TM5 R => P missense 8.367e-06 1 119518 0 0.15 0.862
adrb1_human 222 5.36x37 TM5 R => Q missense 8.367e-06 1 119518 0 0.67 0.042
adrb1_human 230 5.44x45 TM5 V => A missense 1.67e-05 2 119744 0 0.01 0.297
adrb1_human 237 5.51x51 TM5 L => Q missense 8.375e-06 1 119398 0 0.0 0.987
adrb1_human 238 5.52x52 TM5 C => S missense 5.864e-05 7 119378 0 0.03 0.003
adrb1_human 239 5.53x53 TM5 I => V missense 8.386e-06 1 119246 0 1.0 0.0
adrb1_human 241 5.55x55 TM5 A => D missense 8.425e-06 1 118694 0 0.0 0.452
adrb1_human 243 5.57x57 TM5 V => L missense 8.443e-06 1 118440 0 0.0 0.373
adrb1_human 246 5.60x60 TM5 R => Q missense 8.513e-06 1 117474 0 0.0 0.994
adrb1_human 247 5.61x61 TM5 V => M missense 8.532e-06 1 117204 0 0.0 0.968 GP (contact)
adrb1_human 249 5.63x63 TM5 R => G missense 8.595e-06 1 116348 0 0.05 0.874
adrb1_human 254 5.68x68 TM5 Q => H missense 8.88e-06 1 112612 0 0.15 0.891 GP (contact)
adrb1_human 260 5.74x74 TM5 S => N missense 1.905e-05 2 104970 0 0.01 0.204 PTM (Phosphorylation) GP (contact)
adrb1_human 261 ICL3 C => Y missense 9.612e-06 1 104040 0 0.03 0.982
adrb1_human 267 ICL3 G => C missense 1.097e-05 1 91190 0 0.06 0.025
adrb1_human 267 ICL3 G => R missense 2.193e-05 2 91190 0 0.37 0.406
adrb1_human 267 ICL3 G => S missense 1.097e-05 1 91190 0 0.8 0.003
adrb1_human 268 ICL3 G => D missense 1.296e-05 1 77172 0 0.26 0.156
adrb1_human 270 ICL3 A => T missense 0.002791 208 74534 1 0.59 0.002
adrb1_human 270 ICL3 A => E missense 1.403e-05 1 71276 0 1.0 0.005
adrb1_human 275 ICL3 P => S missense 8.486e-05 1 11784 0 0.73 0.736
adrb1_human 304 ICL3 G => A missense 0.0005388 1 1856 0 0.03 0.234
adrb1_human 313 6.24x24 TM6 R => P missense 0.0001752 2 11418 0 0.0 0.961
adrb1_human 316 6.27x27 TM6 A => S missense 6.771e-05 1 14768 0 0.06 0.962
adrb1_human 318 6.29x29 TM6 R => C missense 5.751e-05 1 17388 0 0.0 0.901 GP (contact)
adrb1_human 319 6.30x30 TM6 E => D missense 4.776e-05 1 20936 0 0.05 0.995 SodiumPocket MicroSwitch
adrb1_human 330 6.41x41 TM6 M => V missense 2.043e-05 1 48940 0 0.0 0.981 LB (hydrophobic, Van der Waals, aromatic (face-to-edge), polar (hydrogen bond))
adrb1_human 332 6.43x43 TM6 V => D missense 3.498e-05 2 57182 0 0.0 0.95
adrb1_human 336 6.47x47 TM6 C => Y missense 1.421e-05 1 70350 0 0.0 0.999
adrb1_human 343 6.54x54 TM6 A => V missense 1.142e-05 1 87566 0 1.0 0.037
adrb1_human 345 6.56x56 TM6 V => M missense 1.105e-05 1 90468 0 0.0 0.985
adrb1_human 348 6.59x59 TM6 A => S missense 8.45e-05 8 94678 0 0.1 0.555
adrb1_human 348 6.59x59 TM6 A => T missense 1.056e-05 1 94678 0 0.09 0.297
adrb1_human 353 ECL3 L => M missense 9.848e-06 1 101548 0 0.07 0.671
adrb1_human 354 ECL3 V => M missense 9.743e-06 1 102634 0 0.01 0.982
adrb1_human 358 7.34x33 TM7 L => F missense 9.335e-06 1 107120 0 0.0 0.989
adrb1_human 362 7.38x37 TM7 F => L missense 9.16e-06 1 109172 0 1.0 0.066
adrb1_human 364 7.40x39 TM7 W => C missense 9.093e-06 1 109972 0 0.0 0.999
adrb1_human 370 7.46x46 TM7 S => P missense 8.976e-06 1 111410 0 0.0 0.999
adrb1_human 371 7.47x47 TM7 A => V missense 8.965e-06 1 111544 0 0.0 0.999
adrb1_human 373 7.49x49 TM7 N => D missense 8.949e-06 1 111744 0 0.0 0.997 SodiumPocket MicroSwitch
adrb1_human 380 8.47x47 H8 S => R missense 2.683e-05 3 111808 0 0.0 0.999 GP (contact)
adrb1_human 382 8.49x49 H8 D => G missense 0.0005634 63 111822 1 0.02 0.999 GP (contact)
adrb1_human 384 8.51x51 H8 R => H missense 8.95e-06 1 111726 0 0.0 0.999 GP (contact)
adrb1_human 384 8.51x51 H8 R => L missense 8.95e-06 1 111726 0 0.0 0.999 GP (contact)
adrb1_human 385 8.52x52 H8 K => E missense 1.788e-05 2 111858 0 0.25 0.542
adrb1_human 390 8.57x57 H8 L => P missense 1.885e-05 2 106120 0 0.0 0.994
adrb1_human 391 8.58x58 H8 L => F missense 9.484e-06 1 105438 0 0.0 0.999
adrb1_human 392 8.59x59 H8 C => R missense 9.543e-06 1 104792 0 0.04 0.999
adrb1_human 392 8.59x59 H8 C => Y missense 9.606e-06 1 104102 0 0.04 0.999
adrb1_human 393 C-term C => W missense 9.739e-06 1 102678 0 0.04 0.823
adrb1_human 394 C-term A => S missense 9.805e-06 1 101984 0 0.35 0.254
adrb1_human 395 C-term R => C missense 9.947e-06 1 100534 0 0.0 0.994
adrb1_human 395 C-term R => L missense 2.991e-05 3 100292 0 0.0 0.963
adrb1_human 395 C-term R => H missense 0.0001097 11 100292 0 0.01 0.987
adrb1_human 397 C-term A => T missense 2.043e-05 2 97888 0 0.03 0.398
adrb1_human 399 C-term R => H missense 2.096e-05 2 95402 0 0.08 0.891
adrb1_human 401 C-term R => P missense 1.087e-05 1 91986 0 0.2 0.104
adrb1_human 403 C-term A => V missense 1.164e-05 1 85926 0 0.14 0.012
adrb1_human 404 C-term T => A missense 1.319e-05 1 75832 0 0.75 0.0 PTM (Phosphorylation)
adrb1_human 408 C-term R => P missense 2.542e-05 1 39344 0 0.25 0.001
adrb1_human 409 C-term P => L missense 3.986e-05 1 25090 0 0.11 0.085
adrb1_human 410 C-term R => H missense 5.548e-05 1 18024 0 0.12 0.955
adrb1_human 416 C-term A => T missense 0.0009785 1 1022 0 0.54 0.069


Residue

Diagrams

ICL1 P R L Q ICL1ECL1 R W E Y ECL1ICL2 P F R Y Q S L L ICL2ECL2 W W R A E S D E A R R C Y N D P K C C D F V T ECL2ICL3 C E R R F L G G P A R P P S P S P S P V P A P A P P P G P P R P A A A A A T A P L A N G R A G K R R P S ICL3ECL3 R E L V ECL3N-term M G A G V L V L G A S E P G N L S S A A P L P D G A A T A A R L L V P A S P P A S L L P P A S E S N-termC-term C A R R A A R R R H A T H G D R P R A S G C L A R P G P P P S P G A A S D D D D D D V V G A T P P A R L L E P W A G C N G G A A A D S D S S L D E P C R P G F A S E S K V C-term P E P L S Q Q W T A G M G L L M A L I V L L I V A G N V L V I V A I A K T T L T N L F I M S L A S A D L V M G L L V V P F G A T I V V W G G S F F C E L W T S V D V L C V T A S I E T L C V I A L D R Y L A I T S T R A R A R G L V C T V W A I S A L V S F L P I L M H N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S R L V A L R E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H P D R L F V F F N W L G Y A N S A F N P I I Y C R S P D F Q R F R K A L L C
SnakePlot Download: PNG | SVG V N G A V I L L V I L A M L L G M G A T 1 M S L A S A D L V M G L L V V P F G A T I 2 V C L T E I S A T V C L V D V S T W L E 3 A R G L V C T V W A I S A L V S F L P I 4 Y V F A M I C L P V Y F S V V S S A I A Y 5 G I I M G V F T L C W L P F F L A N V V 6 I P N F A S N A Y G L W N F F V F L R 7
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